PARP INHIBITOR OLAPARIB OVERCOMES SORAFENIB RESISTANCE THROUGH RESHAPING THE PLURIPOTENT TRANSCRIPTOME IN HEPATOCELLULAR CARCINOMA

PARP inhibitor Olaparib overcomes Sorafenib resistance through reshaping the pluripotent transcriptome in hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) is one of the most common Mirror human malignancies worldwide with very poor prognosis.Resistance to targeted therapeutic drugs such as sorafenib remains one of the major challenges in clinical treatment.In the present study, PARP1 was found to be highly expressed in human embryonic stem cells, but progressiv

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Alternative eradication regimens for Helicobacter pylori infection in Indonesian regions with high metronidazole and levofloxacin resistance

Muhammad Miftahussurur,1,2 Langgeng Agung Waskito,2,3 Ari Fahrial Syam,4 Iswan Abbas Nusi,1 Gontar Siregar,5 Marselino Richardo,6 Achmad Fuad Bakry,7 Yudith Annisa Ayu Rezkitha,2,8 I Dewa Nyoman Wibawa,9 Yoshio Yamaoka3,10,11 1Division of Gastroentero-hepatology, Department of Internal Medicine, Faculty of Medicine, Dr.Soetomo Teaching Hospital, Un

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